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Senin, 20 Februari 2012

Download , by Cheryl Hunter

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File Size: 336 KB

Print Length: 48 pages

Publisher: Venator (March 19, 2016)

Publication Date: March 19, 2016

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Language: English

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#814,508 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

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Rabu, 15 Februari 2012

Ebook

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File Size: 4595 KB

Print Length: 304 pages

Publisher: Blackmore Dennett (March 19, 2019)

Publication Date: March 19, 2019

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Language: English

ASIN: B07PXJP9YC

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Amazon Best Sellers Rank:

#562,149 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

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Kamis, 09 Februari 2012

Download Energy and Civilization: A History

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Energy and Civilization: A History


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Audible Audiobook

Listening Length: 20 hours and 9 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: Gildan Media

Audible.com Release Date: May 8, 2018

Language: English, English

ASIN: B07CMXCWK2

Amazon Best Sellers Rank:

This is one of those books which should be widely read; a concise explanation of “energy” as relates to society beginning with terms and definitions which most people do not consider. Smil starts with the obvious (but often overlooked) statement that we on earth have no source of energy which is not provided by the sun in some form or another.From there, we start with the calculations regarding the number of calories any human needs to get through the day; pretty basic and clearly explained values.This is followed by the overall history of energy in human society, beginning with foraging and scavenging societies, using human muscle energy in more effective forms as a result of human reasoning; tools. Accompanied by (largely effective) sidebar notes, the narrative then progresses through the use of draft and ridden animal muscle, direct water and wind power, and then on to the use of ‘stored’ solar energy in the form of carbon and radioactive fuels, to the present. The fragility of society prior to modern use of those ‘stored’ sources is eye-opening and should serve as a corrective to anyone hoping to return to some romantic, pristine, autarky.I’m sure this was not intended for the general audience; the terminology and notation suggests and requires a certain level of education. But at times Smil seems to change units of measure in what looks a bit of braggadocio. Joules, calories, watts, any will do, but switching back and forth requires mental gymnastics and introduces the chance of errors; there is no reason to make a book less understandable than the transfer of information requires.Similarly, there is no reason for the pedantry regarding the phrase “Industrial Revolution”; I recall no one using the phrase to mean a ‘revolution’ in X years. As it was intended to mean a rapid change in many social arrangements, it was just that and is a useful shorthand for that phenomenon.Disregarding such caviling, we are, at well-researched and well-argued length, presented with the uncontroversial fact that we are consuming carbon energy resources far beyond replacement rates and that use is resulting in environmental problems which could be very serious. Fortunately, the author is not given to hyperbole; those environmental problems are neither certain in time or severity.But as Smil makes clear, there are really few alternatives. Our recent fantasies regarding wind or solar are never going to provide the energy surplus we currently enjoy, even if we had 100% battery storage technology. There is simply not enough ‘instant’ solar energy available to support the style to which we have become accustomed and others hope to achieve.Citing some studies regarding ‘happiness’ vs wealth which I find far from convincing, the author seems to come down on the side of drastically reduced energy consumption. He never suggests coercion to achieve that end, but it’s doubtful that those who are used to luxury and those who quest for it are likely to voluntarily reduce that standard of living or the desire for it, regardless of Smil’s personal (righteous!) choice of a 1Kw automobile.Begging to differ, I come down on the ‘let’s develop non-carbon energy’ side; nuclear. And if we are to prevent those possible environmental problems, we’d better get going on developing safe nuclear energy right now, rather than whingeing about the morality of Exon’s profit margin.

I purchased this book based on a recommendation by Bill Gates. It's very interesting and takes you through the history of how humans have used and transformed energy and how that increasingly efficient energy use has advanced societies (and where it hasn't).Be aware that it is very technically dense with a lot of specifics and almost reads like a textbook so it's not what I would call a "light read" but if you like that sort of thing than this book is recommended.

I am only 70% through the book, knowing that the rest will touch upon the noton that our dependence on a very high consumption of energy based on fossil fuels is unsustainable and that renewables gives only some comfort to this conclusion. As an economist I truly which that this perspective was more commonly available through education, as the available energy influcence on economic wealth and especially a long term perspective on this is severly overlooked in todays financial world.So thumbs up, 5 stars, is given to the author for puting the whole energy history in context, and how vital it is to appreciate our fossil fuel workhorses for now and it also led to my appreciation that we can use the energy surplus as today to prepare for a sustainable future of tomorrow. Even with less energy, it is possible to sustain a civilisation based on "energy helpers" so that living standards are still acceptable. The calculations back and forth when it comes to Joules/tons/kwh (or even barrels) is very useful for engaging the mind outside speed reading. An eye opener for me was the 90% energy conversion for electricity for kinetic energy as opposed to 40% for diesel and 25% for gasoline. Going electric for personal transportation based on renewables really makes sense overall!

Truly fascinating. It is hard to describe how impressive this masterful history is. A summation of a world of knowledge in a thorough, understandable, and context-rich book. Required reading for anyone interested in energy, sustainability, and the future of humanity.

Based on my previous Vaclav Smil reading, I was expecting (hoping) for more of a big-picture technical survey (along the line of "the physics of building and maintaining civilizations"). I was somewhat disappointed to discover a conventional historical narrative of the discovery and exploitation of the various familiar energy sources. Admittedly, more a case of missed expectations rather than any specific shortcoming of the book.

I was really disappointed in this book. It’s a history and is full of facts that seem almost randomly addressed. There is a lot of interesting information, but none of it seems to have a point , it’s just a collection of data. The citations are probably important to someone, but to a non academic they are just irritating and disrupt the flow of the text. I found Richard Rhodes’ book Energy:a human history much more informative and much much more entertaining.

As a mechanical engineer, I was taught a lot about energy and worked with it my whole career. I've always loved history as well. Now, I read a book that traces the human story along with the thread of how energy is found, grown, used, eaten, wasted...all that...and really dominates society in so many ways. This is a book long on detail so some may feel overwhelmed by it. My favorite part was the last 20% where the author appears to summarize the influence of energy on all the major domains of civilization. A book that I am keeping for reference and rereading.

Vaclav Smil’s books are always enjoyable. He demonstrates that the material civilisation that we have is the result of people acquiring the means of energy production. Yet he is also aware that energy is not the only thing that matters - it matters much, but the way it is used also depends on the culture and society.

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Senin, 06 Februari 2012

Download The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines

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Review

The dearth of promising new treatments for many a serious disease remains a major challenge not just for the pharmaceutical industry but for all of society. In this exhaustively researched book, Brent R. Stockwell surveys the history of drug development and offers insightful suggestions for innovative new approaches. This is critical reading for the many involved in and concerned about this urgent issue. (Robert Bazell, chief science correspondent, NBC News, and author of Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer)This is a terrific book! Stockwell's writing is clear and engaging as he presents a thoughtful analysis of drug development that can be understood and appreciated by a diverse readership. Stockwell beautifully combines scientific history and personal anecdotes with clear explanations of the principles and practices of chemical biology to make a fascinating story of the past, present, and future of drug discovery. His book is informative, accurate, and a good read all put together. (Geoffrey Cooper, Boston University, author of The Cell: A Molecular Approach and Oncogenes)This is a truly wonderful book. Stockwell's writing will open the door to a universe that many readers may know little about. Drugs are born, biotech companies are created, scientists' careers are made and unmade, egos are raised and dashed. This book is so readable, it is an absolute page-turner. Yet it is also authoritative and scientifically sophisticated, managing to distill a complex, changing field into a beautifully written, well-crafted story. (Siddhartha Mukherjee, Columbia University, author of The Emperor of All Maladies: A Biography of Cancer)By providing accessible explanations for the underlying biological and chemical principles that apply to the complex solutions he describes, Stockwell enables even the scientifically unsophisticated reader to gain a wider perspective on what future disease treatment might entail. (Publishers Weekly)This very readable, even exciting work takes us through the medical breakthroughs of the past century. (Globe and Mail)This book deserves a readership, and there is certainly a need for it. As a drug companyresearcher, I have often wished that more people understood what the field was likeand how simultaneously fascinating and frustrating it can be. (Derek B. Lowe Cell)In this well-researched look into the complexities of making medicines, a chemical biologist gives a history of drug making and details innovative methods of drug discovery. (Science News)Despite our current political paralysis, government leaders should listen to Stockwell and be certain to advance our capacity to generate the drugs that our society and the world need. (Harvard Magazine)The book is well organized and includes many interesting, clever analogies to explain what can be complicated scientific problems. (Choice)An engaging and rewarding read... (Donald C. Lo Journal of Clinical Investigation)

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About the Author

Brent R. Stockwell is an associate professor of biological sciences and chemistry at Columbia University and a Howard Hughes Medical Institute Early Career Scientist. He serves on the editorial board of Chemistry & Biology, has been awarded ten U.S. patents, and has published fifty-four scientific papers. Among his recent honors are a Burroughs Wellcome Fund Career Award at the Scientific Interface and a Beckman Young Investigator Award.

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Product details

Paperback: 284 pages

Publisher: Columbia University Press (January 1, 2013)

Language: English

ISBN-10: 0231152132

ISBN-13: 978-0231152136

Product Dimensions:

5.2 x 0.8 x 8 inches

Shipping Weight: 9.6 ounces (View shipping rates and policies)

Average Customer Review:

3.5 out of 5 stars

16 customer reviews

Amazon Best Sellers Rank:

#1,029,915 in Books (See Top 100 in Books)

I bough the book so that I can introduce some examples in my lectures on insilico drug design. I enjoyed reading the book, and I have learned something. The professionals can enjoyed reading this book, but also the text should be understandable to the wide audience. I enjoyed that author has presented science and a little of real life stories behind the science.I gave the book four stars, instead of 5 since the author primarily covered areas of his research experience, Most notably there is nothing on different computational methods that have been in development in the last 30 years, also computational methods are not included in discussing the future. I would not go into analysis why computational methods are missing, Simply this book is interesting, and it could have been great if some areas are not missing.In conclusion, if there is a second edition, with few additions it could be a great text to read.Good luck in your lives folks, Cheers.

Many books have been written about the development of new pharmaceuticals. It seems that a majority of these books focus on the scientist and business people involved in the industry and on the deadly diseases that these people are trying to cure. Not so with this book. This book focuses more on the discoveries and technology that make drug development possible.Dr. Stockwell took the time in his book to explain the technology involved in discovering (or generating?) new drugs. You are going to finish this book knowing a lot more about biotechnology than when you started. That said, I can imagine that this book would be challenging to read to people outside the scientific community (I myself am a student).I was a bit disappointed with the ending of the book. The author took great care to painstakingly explain several new important technologies. Then, at the end of the book, the author listed several other remaining technologies, all important, without describing them. I wished he would have spent more time explaining the future uses of siRNA and gene therapy. This is probably because these areas of research are outside the authors field of work, which I infer is Chemistry and not biology.I recommend this text to anyone interested in the drug discovery field.

A great book. The author writes accessibly for the lay person and makes his tale interesting. My son is studying chemical engineering and is interested in biomedical topics, so we are enjoying reading about current happenings in the search for cures to difficult diseases. I appreciate the level of detail presented with the care taken to explain things as directly as possible. I have learned a lot. It is instructive and inspiring to learn of the author's early ambitions, lessons learned and his successes.

Brilliant! I bought this book because I wanted a better understanding of the drug development process. I thought it was going to be an interesting, but difficult, dense topic. To my amazement the author made very complex topics immensely understandable and pleasurable to learn about.It instilled in me a sense of curiosity and wonderment in the drug development process that I never imagined before. Chemistry and biology stopped being dry, rote topics and became living breathing subjects that affect my everyday well-being.Congratulations to the author for his mastery in explaining these challenging topics in easy to understand, accessible language. The book is a great accomplishment.

Not bad to learn the acitivities at pharmaceutical companies, but to broad topics.

I like the way Brent writes; my recommendation is to focus on less known stories in drug development. However, this is only a minor issue and I honestly recommend this book to professionals as well as the lay audience.

This is just a wonderful book! It is a delightful reading that will take you from the beginning of the drug discoveries to the latest researches in molecular biology.It is also a book of hope! Step by step, we are discovering the inner workings of the machinery of life.

This is a well written history of drug discovery and future prospects for drugging the undrugable. In summary, there are a lot of drugs but they target only a small percentage of possible targets. Many scientists think that most of the other targets are undrugable and that we will never develop drugs for them. This means that our options for curing diseases from cancer to MS etc are limited or non-existent. The author goes over the history of drug discovery and describes the latest technology that offers hope that the currently undrugable targets may become drugable. It is very wide ranging and thorough with an optimistic ending. The figures could be better and although it is written for the layman it is referenced for the expert which is a little strange.

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The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines PDF

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The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines PDF
The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicines PDF

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